Lab Scientist, Microscopy

Roche Holding AG; Basel; On-site; CHF 120,000 - 160,000; Full time

Job summary

Roche Holding AG recherche un scientifique senior expérimenté pour la Microscopy Technology Platform au sein du chapitre 360 Labs, SPO, pRED. Vous concevrez et optimiserez des flux de travail en microscopie pour des structures biologiques variées et travaillerez en étroite collaboration avec des experts multidisciplinaires.

Le candidat idéal possède une formation avancée en biologie/chimie/physique et une expertise pratique des techniques de microscopie et des méthodes d’analyse d’images.

Qualifications

• Détenteur d’un MSc ou d’un doctorat en biologie, chimie ou physique, avec 5+ ou 3+ années d’expérience selon le diplôme.
• Connaissance approfondie des techniques de microscopie optique (widefield, confocale, multiphoton) et adaptation à différents types d’échantillons biologiques.
• Capacité à collaborer au sein d’équipes matricielles et à communiquer en anglais de manière fluide.

Responsibilities

• Former les utilisateurs de la plateforme à l’utilisation des microscopes et des approches de fluorescence.
• Soutenir la planification, le développement, l’exécution et la validation de flux de travail expérimentaux.
• Garantir la production continue de données FAIR et réaliser le contrôle qualité des instruments et des workflows.
• Rester informé des avancées technologiques et des publications pertinentes dans le domaine.

Skills

Optical microscopy

English fluency

Cross-functional collaboration

Education

MSc or PhD in biology/chemistry/physics

Tools

Widefield microscopy

Confocal microscopy

Multiphoton imaging

Live-cell imaging

Job description

Chez Roche, vous pouvez être vous-même et être apprécié pour les qualités uniques que vous apportez. Notre culture encourage l'expression personnelle, le dialogue ouvert et les connexions authentiques, où vous êtes valorisé, accepté et respecté pour ce que vous êtes, vous permettant de prospérer tant personnellement que professionnellement. Voici comment nous visons à prévenir, arrêter et guérir les maladies et à garantir à chacun l'accès aux soins de santé aujourd'hui et pour les générations à venir. Rejoignez Roche, où chaque voix compte.

La position

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Strategy, Portfolio & Operations (SPO) is a unified function that serves as the strategic and operational backbone enabling pRED's strategy from lab to clinic. Operating under a dynamic Chapter Model, SPO centralizes specialized skills across critical areas including Sites & Lab Services, Program & Project Management, Strategy, Clinical Operations, External Operations, Capability Development, Core Lab Technology Platforms (360Labs) and Asset Team Leadership. SPO’s mission is to drive enterprise value creation by delivering operational excellence, and accelerating portfolio productivity. As a trusted partner, SPO fosters a culture of collaboration and accountability to ensure pRED transitions assets smoothly from early research to late-stage development.

360 Labs Chapter at a Glance

The primary mission of the 360 Labs Chapter within SPO is to provide greater access and support for the use of cutting-edge biomedical research technologies by scientists across our discovery portfolio. 360 Labs delivers core scientific technologies, expertise and enabling activities, as well as facilitating knowledge sharing in close collaboration with our therapeutic areas and functions. Our ambition is to bring to life a thriving workplace environment, where your collaborative mindset is as valued as your professional expertise. Our goal is to act as a highly integrated ecosystem, supporting research and development, working collaboratively, and focused on fostering excellence and sustainability. Together, these efforts will serve to increase the speed, enhance the robustness and improve the sustainability of our exploratory research and early discovery activities.

The Opportunity

The Microscopy Technology Platform in the 360 Labs Chapter is seeking an experienced, highly motivated, collaborative, and customer-centric lab-based senior scientist. The successful candidate will have a strong theoretical and practical background in the use of state-of-the-art optical microscopy techniques. Candidates with a solid understanding of how to best design and execute optical microscopy-based assays as applied to a variety of 2D and 3D sample types (including complex cell and organoid cultures and fixed cell/tissue preparations) are strongly desired. You will work with a sense of urgency as part of a matrix team, collaborating with specialists from each of our therapeutic disease areas and functions to advance early drug discovery programs, and you will also contribute to the ongoing development and operations of the Microscopy Technology Platform within the pRED organisation.

Your Role and Responsibilities:

• You will provide in-depth training to platform users in the appropriate use of both optical microscope instrumentation and fluorescence-based microscopy approaches;
• You will support platform users in the planning, development, execution, and validation of both routine and custom workflows concerning fluorescence microscopy-based assays and experiments, as well as engage with stakeholders to present and discuss findings in a dynamic and flexible manner;
• You will ensure the continued production of high-quality FAIR research data by performing regular quality control and troubleshooting of optical microscopy instruments and workflows;
• You will embrace a continuous learning mindset by actively engaging with the scientific literature to stay abreast of emergent technologies/approaches in the advanced optical microscopy field.

Who You Are

• You hold an MSc or PhD degree in biology, chemistry or physics, with either 5+ or 3+ years of experience, respectively, focused on fluorescence-based optical microscopy approaches, either in an academic research laboratory/core facility setting and/or the pharmaceutical industry/biotech sector;
• You possess in-depth theoretical and proven hands-on knowledge in a variety of optical microscopy techniques and their adaptation across various biological sample types. Specifically, robust experience in the use of widefield, confocal microscopy (both laser-scanning and live-cell spinning disk) as well as multi-photon/label-free imaging is required. Further experience with super-resolution imaging, fluorescence lifetime Imaging, and feedback microscopy workflows is highly desired;
• You have a proven ability to collaborate within and across matrix teams, including molecular biologists, microscopists, research histopathologists, and image analysis experts, educating scientists on optical microscopy instruments and workflows, as well as in designing experiments based on complex research questions, including interpretation of results.

In addition to your scientific expertise and critical technical skills, we are looking for candidates who are:

• Customer-focused with a drive for growth and a questioning mindset. Skilled in creative problem-solving, organisation, and implementing innovative ideas efficiently in a fast-paced research context;
• Excellent communicators with a high fluency in English, a desire to continuously build a personal network, and the ability to thrive in a dynamic, inclusive environment which gives you full accountability for your own contributions and development.

At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you.

Qui nous sommes

Un avenir plus sain nous pousse à innover. Ensemble, plus de 100 000 employés à travers le monde sont dédiés à faire progresser la science et à garantir à chacun l'accès aux soins de santé aujourd'hui et pour les générations à venir. Nos efforts aboutissent à plus de 26 millions de personnes traitées avec nos médicaments et plus de 30 milliards de tests réalisés avec nos produits de Diagnostique. Nous nous encourageons mutuellement à explorer de nouvelles possibilités, à favoriser la créativité et à conserver nos grandes ambitions, afin de fournir des solutions de santé qui changent des vies et ont un impact mondial.

Construisons ensemble un avenir plus sain.

Roche est un employeur offrant l'équité en matière d'emploi.