Intern: UV-Vis Soft Sensor & Kinetic Modeling

Merck; Corsier-sur-Vevey; Vor Ort; CHF 18.000 - 27.000; Teilzeit

Zusammenfassung

Merck seeks a master's/engineering student for a 6‑month internship in Corsier-sur-Vevey, focusing on developing a UV-Vis based soft sensor and kinetic models for antibody conjugation processes. You will work with PAT, modelling, and process experts, building Python-based tools and presenting results in project reviews.

Role focuses on data preprocessing, kinetic modelling with gPROMS/Python, and Kalman filtering to fuse measurements with predictions.

Qualifikationen

• Master's student or engineering student in data science, analytical chemistry, biochemistry, biotechnology, or chemical engineering.
• Strong interest in reaction kinetics, mechanistic modelling, dynamic systems, and data science.
• Experience with python and gPROMS or another process modelling tool is a strong plus.
• Interest in spectroscopy and chemometrics; knowledge of UV-Vis or PLS is an advantage.
• Practical laboratory experience and strong attention to data quality and reproducibility.
• Fluent in English

Aufgaben

• Support the development and evaluation of the UV-Vis-based soft sensor, including data preprocessing and chemometric data treatment.
• Develop kinetic reaction models using gPROMS and/or Python to describe the evolution of the conjugation species.
• Compare different kinetic model structures, estimate kinetic parameters, and assess the predictive performance.
• Validate the kinetic model against independent experimental or offline analytical data where available.
• Combine kinetic model with the soft sensor data using an Extended Kalman Filter.
• Evaluate model performance, robustness and limitations, and present results during reviews.

Kenntnisse

Data science

Analytical chemistry

Biochemistry

Biotechnology

Chemical engineering

Python

gPROMS

Process modelling

Kalman filtering

Fluent English

Ausbildung

Pursuing Master's degree in related field

Tools

gPROMS

Python

Jobbeschreibung

Merck seeks a master's/engineering student for a 6‑month internship in Corsier-sur-Vevey, focusing on developing a UV-Vis based soft sensor and kinetic models for antibody conjugation processes. You will work with PAT, modelling, and process experts, building Python-based tools and presenting results in project reviews.

Role focuses on data preprocessing, kinetic modelling with gPROMS/Python, and Kalman filtering to fuse measurements with predictions.