Bioinformatics and Molecular Modelling Specialist in Process Chemistry & Catalysis (two years t[...]

Roche; Basel; Vor Ort; CHF 100’000 - 130’000; Vollzeit

Zusammenfassung

A leading global healthcare company in Basel is seeking a highly skilled scientist to join their Process Chemistry & Catalysis department. The role involves leading biocatalytic innovation and utilizing advanced computational chemistry to enhance drug substance processes. Candidates must hold a PhD in synthetic chemistry or related fields, possess strong bioinformatics skills, and be proficient in data analysis tools. Excellent teamwork and communication in English and German are essential. This full-time position offers opportunities to make impactful contributions in healthcare.

Qualifikationen

• Strong publication record in peer-reviewed journals and/or patents.
• In-depth expertise in data gathering and analysis tools.
• Knowledge of enzyme engineering techniques.

Aufgaben

• Lead biocatalytic innovation for drug substance processes.
• Design and oversee enzyme libraries for process development.
• Utilize computational chemistry for enzyme engineering.

Kenntnisse

Expert in bioinformatics

Machine Learning techniques

Data analysis and visualization

Team collaboration

Ausbildung

PhD in synthetic chemistry or related field

Tools

Spotfire

SQL or MongoDB

Jobbeschreibung

The Position

At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.

The Opportunity

Join the Process Chemistry & Catalysis department a crucial part of the Synthetic Molecules Technical Development (PTDC) organization within Pharma Global Technical Operations (PT). You’ll be instrumental in developing robust and cost-effective Drug Substance processes for our small molecules, peptides and oligonucleotides pipeline from clinical entry to commercial manufacturing.

• Lead Biocatalytic Innovation: Be the expert to identify, create and design novel enzymes/enzymatic processes enabling the efficient synthesis of our portfolio molecules for clinical and commercial supply.
• Design High-Quality Enzyme Libraries: Drive the quality and diversity of our enzyme libraries overseeing the design of ready-to-screen enzyme plates to accelerate process development.
• Apply Computational Chemistry Expertise: Utilize structure-based computational chemistry to predict key amino acid positions for enzyme engineering, optimizing activity, selectivity and stability under various process conditions.
• Develop Advanced Computational Models: Create reaction-specific enzyme libraries using cutting-edge protein structure and experimental data, advanced modeling and simulation techniques.
• Maintain State-of-the-Art Infrastructure: Ensure the stability and functionality of our state-of-the-art software infrastructure essential for all required molecular modeling and simulation tasks.
• Leverage Data Science for Prediction: Implement data analysis and Machine Learning/AI methods to enable accurate enzyme activity prediction based on existing experimental data.
• Drive Process Development and Screening: Act as a core member of project teams managing the screening, efficient data processing, hit identification and verification to develop enzyme-catalyzed processes suitable for high-quality manufacturing.
• Serve as Data Analytics Specialist: Provide first-level support for data gathering, mining, analysis and visualisations (Spotfire experience is a plus) for the entire catalysis group fostering a data-driven environment.

Who You Are

You are a highly skilled scientist ready to apply your deep expertise in bioinformatics and molecular modeling to real-world drug development challenges within a dynamic interdisciplinary team.

• You hold a PhD in synthetic chemistry, bioinformatics, biocatalysis or molecular biology demonstrated by a strong publication record in peer‑reviewed journals and/or patents.
• You are an expert in bioinformatics specifically applying phylogenetic analysis of protein families to accurately infer distant homologs and orthologues.
• You possess in‑depth expertise in sequence modeling de novo, prediction, visualization and analysis of protein structures, small‑molecule docking and molecular dynamics simulations of protein‑ligand complexes.
• You have profound practical knowledge in data gathering, mining, analysing and visualization tools including Spotfire and experience with common databases such as SQL and/or MongoDB.
• You are experienced in applying Machine Learning/Artificial Intelligence tools and concepts ideally extending beyond enzyme catalysis to solve complex biological problems.
• You bring desired experience in industrial biocatalysis or bioinformatics preferably with hands‑on experience in biotransformations (mg to multi‑g scale) and knowledge of enzyme engineering techniques.
• You are an excellent team player with strong coordination and communication skills demonstrating proficiency in both English and German.

Who we are

A healthier future drives us to innovate. Together more than 100,000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity and keep our ambitions high so we can deliver life‑changing healthcare solutions that make a global impact.

Lets build a healthier future together.

Roche is an Equal Opportunity Employer.

Employment Type: Full-Time