Sr. Scientist, Biology

Fusion Pharmaceuticals; Hamilton; On-site; CAD 80,000 - 100,000; Full time

Job summary

A clinical-stage oncology company in Hamilton is seeking an independent technical lead for radio conjugate research programs in oncology. The ideal candidate holds a Ph.D. in cancer or radiation biology and has over 3 years of relevant experience. The role involves strategic program execution, collaboration with internal and external partners, and the application of expertise in cancer biology to advance research objectives. Strong communication skills and experience in a fast-paced research setting are essential for this position.

Qualifications

• 3+ years of relevant work experience in oncology research.
• Strong knowledge of cancer and/or radiation biology.
• Experience designing efficacy studies in mouse cancer models is a plus.

Responsibilities

• Lead radio conjugate research programs in oncology.
• Drive strategy and execution from concept to decision points.
• Collaborate with internal teams and external partners.

Skills

Cancer biology expertise

Problem-solving skills

Communication

Experience in cancer cell culture

Collaboration

Education

Ph.D. in cancer or radiation biology

Tools

Flow cytometry

ELISA

Western blotting

In vitro bioassays

Job description

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes but is not limited to: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. Fusion has multiple other pipeline programs that will soon be entering into early FIH trials. In addition, Fusion is pursuing combination programs between RCs and other therapeutic modalities including DNA Damage Response Inhibitors (DDRis) and immune‑oncology agents. To support execution for these programs, Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state‑of‑the‑art radioconjugate manufacturing facility to meet supply demand for our growing pipeline of RCs.

Responsibilities

• Independent technical lead for radio conjugate (RC) research programs in oncology, driving strategy and execution from concept to decision points
  • Apply creative thinking and scientific expertise to understand RC biology such as mechanisms of action, determinants of drug sensitivity and resistance, and rational combination strategies
  • Collaborate closely with cross‑functional internal teams and external partners by setting clear objectives, delivering robust data packages, and communicating results to agreed timelines
  • Present program updates and scientific results at internal governance meetings, project team forums, and external scientific conferences

Qualifications

• Ph.D. in a cancer or radiation biology (or closely related field) with 3+ years of relevant work experience
• Strong knowledge of cancer and/or radiation biology, with a demonstrated commitment to continued learning
• Expertise in cancer cell culture, development & technical validation of fit‑for‑purpose in vitro bioassays, and combination drug testing
• Proficiency with molecular and histology assays, including cytotoxicity assays, receptor binding and internalization, flow cytometry, ELISA, Western blotting and IHC
• Experience designing and interpreting efficacy studies in mouse cancer model is an asset
• Proven ability to thrive in a fast‑paced, evolving research environment with strong problem‑solving and prioritization skills
• Excellent verbal and written communication, with a track record of clear data presentation and scientific storytelling
• Experience working in multidisciplinary, collaborative teams and communicating effectively with colleagues at all levels
• Ability to partner and manage external CRO’s is an asset
• Experience with safe handling of radioactive and biohazardous materials is an asset

Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier‑free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.