Research Associate: Quantum Tunnelling in Enzymes (Hybrid)

The University of Manchester; Manchester; Hybrid; CAD 55,000 - 80,000; Full time

Job summary

A leading research university in Ontario is seeking a post-doctoral researcher to contribute to enzyme catalysis studies, focusing on quantum mechanical tunnelling. The role includes designing evolution methodologies and measuring enzyme kinetics. Candidates should ideally have experience in directed evolution and enzyme kinetics. This position offers excellent career benefits, including competitive annual leave and pension schemes, with flexible hybrid working arrangements considered.

Benefits

Fantastic market leading Pension scheme

Excellent employee health and wellbeing services

Exceptional starting annual leave entitlement

Additional paid closure over Christmas

Local and national discounts at major retailers

Qualifications

• Experience in directed evolution of enzymes is highly desirable.
• Measurement of kinetic isotope effects (KIEs).
• Experience with high-throughput chromatography is a plus.

Responsibilities

• Design methodology for directed evolution of H-transfer enzymes.
• Measure enzyme activity, kinetics, and isotope effects.
• Perform potential X-ray crystallography experiments.

Skills

Directed enzyme evolution

Measurement of kinetic isotope effects (KIEs)

High-throughput chromatography

Tools

X-ray crystallography

Computational chemistry

Job description

A leading research university in Ontario is seeking a post-doctoral researcher to contribute to enzyme catalysis studies, focusing on quantum mechanical tunnelling. The role includes designing evolution methodologies and measuring enzyme kinetics. Candidates should ideally have experience in directed evolution and enzyme kinetics. This position offers excellent career benefits, including competitive annual leave and pension schemes, with flexible hybrid working arrangements considered.