Overview
Integration of safety into the scale up and manufacture of chemical processes by evaluating and consulting on thermal, chemical and reactive hazards.
Reporting Structure
Reporting to: Senior Manager, Research & Development
Qualification
- B.Sc. and/or M.Sc. in Chemistry, preferably Synthetic Organic or Chemical Engineering degree
Experience
- Postgraduate industrial or academic experience in synthetic organic chemistry is preferred. Experience with scaling up chemical process design at a pharmaceutical and/or fine chemical company is an additional asset
Skills and Knowledge
- Knowledge of synthetic organic chemistry and the methods and techniques involved in preparative organic chemistry
- Knowledge of chemical process safety and the rationale for inherently safe chemical processes and the basis of safety
- Ability to gather thermal, chemical and reactive hazard information from literature sources such as Brethrick’s, RTECS, Material Safety Data Sheets, etc;
- Application of thermal analysis techniques such as DSC, and reaction calorimetry
- Ability to interpret thermal analysis data
- Ability to strictly adhere to safety standards, housekeeping processes and Standard Operating Procedures
- General software application knowledge and experience (e.g. database, word processor). More specific process safety software (ie Leadscope, Sarah, Derek) are an asset
Key Responsibilities
- Conduct theoretical thermal analysis of proposed chemical procedures
- Perform thermal analysis of reaction materials (e.g. raw materials, intermediates, products and reaction mixtures) and/or manage outsourcing of such analysis
- Evaluate thermal stability of reaction materials
- Perform experiments to characterize the thermal behaviour of chemical reactions
- Interpret and document experimental results and observations
- Share conclusions and provide recommendations for the safe introduction of procedures into production
- Maintain process safety laboratory instrumentation
- Consult with others including R+D chemists in the development of a safe, scalable chemical processes
- Participate in opportunities to develop knowledge of process chemistry, current Good Manufacturing Processes (cGMP) and safety
- Contribute to the continuous improvement of process safety systems and procedures
- Perform other duties as assigned