Neurobiology Lead – Drug Discovery

Kapoose Creek Bio; Hamilton; On-site; CAD 120,000 - 240,000; Full time

Job summary

Kapoose Creek Bio in Hamilton, ON is seeking a Scientist to VP level to advance our neural science programs. The role spans hands-on bench work and strategic direction depending on experience, within a cross-disciplinary team across biology, chemistry, and AI.

You will design and apply advanced neural assay systems, build mechanistic insight in disease-relevant models, and contribute to therapeutic strategies for neuropsychiatric and neurodegenerative disorders.

Qualifications

• PhD or postdoctoral training in neuroscience or related field.
• Strong experience in neurobiology and neural model systems (in vitro/ex vivo).
• Background in neurological disease is preferred.
• Track record of impactful scientific work in academia or industry.
• Experience in phenotypic screening, electrophysiology, and high-content imaging is a plus.

Responsibilities

• Design and apply advanced neural and neurobiological assay systems.
• Build mechanistic insight in disease-relevant models.
• Contribute to targeted therapeutic strategies for neuropsychiatric and neurodegenerative disorders.
• Collaborate with interdisciplinary teams across biology, chemistry and AI.
• Help shape experimental and program strategy depending on experience.

Skills

Neuroscience expertise

Neurobiology

Pipeline development

Education

PhD or postdoc

Tools

Electrophysiology techniques

High-content imaging

Multi-omics analysis

Phenotypic screening

Drug discovery

Job description

Scientist to VP level | Full-time

Location: McMaster Innovation Park, Hamilton, ON (On-site)

The Opportunity

We are seeking an exceptional scientist with deep expertise in neuroscience and neurobiology to help expand our capabilities in complex neural systems and advance our growing pipeline.

This is a rare chance to work at the frontier of natural product drug discovery, contributing both at the bench and, depending on experience, at the level of scientific direction.

This role involves collaborating closely with our interdisciplinary team across microbiology, chemistry, and biology. You will design and apply advanced neural and neurobiological assay systems to evaluate the activity of novel compounds, build mechanistic insight in disease-relevant models, and contribute to targeted therapeutic strategies for neuropsychiatric and neurodegenerative disorders.

This May Include Work In Areas Such As

• Neuronal cell models
• Synaptic biology
• Neuroinflammation
• Functional modulation of neural circuits

Depending on your experience, this may extend to helping shape experimental and program strategy.

Qualifications & Requirements

• PhD or postdoctoral training in neuroscience or a related field
• Strong experience in neurobiology and in vitro or ex vivo neural model systems
• Background in neurological disease is preferred
• Track record of impactful scientific work in academia or industry
• Experience in phenotypic screening, electrophysiology, high-content imaging, multi-omics, or drug discovery is an asset

Why Kapoose Creek Bio

We are a dynamic, highly collaborative organization working at the interface of biology, chemistry, and AI, with a shared goal of unlocking new regions of natural chemical space for therapeutic discovery.

If you’re energized by that challenge, we’d love to hear from you. The title and level for this role will be aligned with experience and our existing team structure.