Clinical Pharmacologist - PK/PD Expert

Obsidian; Toronto; On-site; CAD 96,000 - 165,000; Full time

Job summary

Obsidian is seeking a clinical pharmacologist to own multiple workflows, including simulating pharmacology data and drafting dose rationale. You will work with PK/PD datasets, dosing regimens, and exposure–response analyses to ensure clinically plausible outputs that reconcile with efficacy and safety results.

You will author dose selection rationales, concentration and response content, and interaction discussions, while designing prompts and rubrics to assess AI-driven pharmacology tasks.

Qualifications

• MUST have supported pre-market (Phases 1-3) programs as a clinical pharmacologist
• Hands-on PK/PD work, dose selection and escalation
• Exposure–response analysis and protocol/SAP-driven data generation

Responsibilities

• Simulate pharmacology data for PK/PD datasets and dose rationale
• Develop content for drug-drug and drug-disease interaction sections
• Design prompts, golden outputs, and rubrics to evaluate AI agents

Skills

PK/PD analysis

Dose selection

Clinical data generation

Protocol & SAP drafting

Education

PharmD

PhD in pharmacology/pharmacokinetics

MD or equivalent

Tools

NONMEM

R

SAS

Job description

As a clinical pharmacologist on this project, you would own a part in multiple workflows:

1. Clinical Data Generation: we need to simulate the pharmacology layer of each data room, including PK and PD datasets, dosing and escalation regimens, exposure-response relationships, and bioanalytical reports, so that dose rationale and concentration data are clinically plausible and reconcile against the efficacy and safety outputs.

2. Clinical pharmacology task authorship: you must be capable of authoring the dose selection rationale, drug concentration and response sections, and drug-drug and drug-disease interaction content, and designing prompts, golden outputs, and rubrics to quantify the ability of an AI agent attempting to do the same thing.

To be qualified for this role, you must fit the following requirements:

• Location: US, Canada, or France.

• YOE: 5+ required. 10-25 preferred.

• Education: PharmD, PhD in pharmacology, pharmacokinetics or a related field, MD, or equivalent.

• Hourly availability: 20-25 hours/week, minimum. 30+ preferred.

• Experience: MUST have supported pre-market (Phases 1-3) programs as a clinical pharmacologist, with hands‑on PK/PD work, dose selection and escalation, and exposure‑response analysis. First‑in‑human experience strongly preferred. Comfortable working from a protocol and SAP to produce pharmacology data that holds up under expert scrutiny.