Senior Scientist, In Silico Discovery

Johnson & Johnson Innovative Medicine; Beerse; Sur place; EUR 76 000 - 117 000; Plein temps

Résumé du poste

Johnson & Johnson Innovative Medicine seeks two computational Senior Scientists for CADD technology development in In Silico Discovery. Belgium is primary, with California/Pennsylvania considered.

You will build automated structure-based workflows, advancing prototype DMTA cycles to full portfolio deployment while collaborating across global teams. The role emphasizes MD, FEP, co-folding, and AI-enabled workflows, with strong coding skills and a track record in computational drug discovery.

Qualifications

• PhD in computational science or related field.
• Experience with structure-based drug discovery.
• Strong Python programming skills.
• Experience building automated workflows and pipelines.
• Familiarity with CI/CD practices.
• Willingness to travel up to 10% domestically and internationally.

Responsabilités

• Develop automated structure-based modeling workflows from prototypes to deployable solutions.
• Expand automation for new structure-based tools and components.
• Collaborate to implement scientific workflows using scalable architectures.
• Gather requirements and shape future workflow needs for the DMTA environment.
• Ensure workflows align with security and operational standards.
• Explore and advance co-folding in automation and workflows.
• Leverage agentic AI to accelerate development and workflows.
• Collaborate with In Silico Discovery and related teams worldwide.

Connaissances

PhD in comp sci

Structure-based discovery

Python

Automated workflows

CI/CD

Travel 10%

Formation

PhD in computational science

Outils

RDKit

Description du poste

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function

Discovery & Pre-Clinical/Clinical Development

Job Sub Function

Chemical Research

Job Category

Scientific/Technology

All Job Posting Locations

Beerse, Antwerp, Belgium, La Jolla, California, United States of America, Spring House, Pennsylvania, United States of America

Job Description

Senior Scientist, In Silico Discovery, J&J IM

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for humanity.

We have two positions for talented computational Senior Scientists in CADD technology development, joining our cutting-edge In Silico Discovery department within Therapeutics Discovery at J&J. The CADD technology development group is focused on increasing the impact of advanced physics- and structure-based methods, including MD, FEP, and co-folding, across the portfolio, with particular emphasis on sophisticated workflows and automation efforts. Belgium is the primary location but California and Pennsylvania will be considered.

The positions involve developing computational methods and workflows in structure-based drug design, physics-based modeling, and co-folding to advance our early drug discovery portfolio. A particular focus will be structure-based automation within autonomous design-make-test-analyse (DMTA) cycles. The two scientists will play a major role in building structure-based components and workflows for this automated environment. Candidates should understand the computational chemistry steps and tools used in structure-based discovery and have strong coding and development skills to accelerate our efforts in this area. A key objective will be to advance the core automated functionality from its current prototype stage to full portfolio deployment over the coming years. The scientists will work closely with colleagues in IT, ISD Cheminformatics, and platform teams to develop robust solutions. Knowledge of software product development for computational drug discovery would be beneficial. In addition to delivering a functioning automated structure-based workflow to tight timelines, the roles will involve expanding the scope of automation by increasing the proportion of chemistry that can successfully pass through existing tools and by identifying and incorporating new tools into automated workflows. The group will also increase the role of co-folding in automation, and experience in this area would be beneficial.

Responsibilities

• Develop components for automated structure-based modeling workflows, such as ligand preparation, protein preparation, docking, docking selection, and free energy calculations, and advance them from prototypes to deployable solutions.
• Work with colleagues to expand the scope of existing automated components and develop automation for new structure-based tools.
• Collaborate with platform and automation teams to implement scientific workflows using common architectures, reusable services, and enterprise standards.
• Contribute requirements, user feedback, and future workflow needs to shape the evolution of our workflow platform and automated DMTA environment.
• Ensure scientific workflows align with platform strategy, technical standards, security requirements, and operational best practices.
• Work with colleagues to explore and develop the use of co-folding across computational workflows, including future automation efforts.
• Leverage agentic AI to support programming, accelerate development, and expand AI-enabled workflows.
• Work collaboratively across In Silico Discovery with our global CADD, Drug Discovery Data Sciences, Cheminformatics, and In Silico Biologics teams.

Required Skills

• A PhD in computational science, computational chemistry, or a related field.
• Knowledge of structure-based computational drug discovery.
• Strong programming skills, preferably in Python.
• Experience developing automated workflows, pipelines, or scientific applications.
• Familiarity with workflow orchestration frameworks.
• Knowledge of software engineering best practices, including version control, testing, and continuous integration and delivery (CI/CD).
• Strong problem-solving skills and the ability to develop creative, innovative solutions that meet project objectives.
• Ability to travel domestically and internationally up to 10% of the time.

Preferred Skills

• Experience with open-source resources, libraries, and toolkits such as RDKit.
• Experience with modern AI/ML libraries and platforms.
• Experience using agentic AI to support programming and software development.
• Experience in one or more of our key scientific areas, such as free energy methods, virtual screening, or co-folding.
• Postdoctoral research in computational chemistry, industry experience, or other exposure to drug discovery would be beneficial.

Preferred Skills:

• Chemistry
• Collaboration
• Critical Thinking
• Data Quality
• Drug Discovery Development
• Emerging Technologies
• Execution Focus
• Industry Analysis
• Innovation
• Interdisciplinary Work
• Pharmaceutical Trends
• Pharmacognosy
• Pharmacology
• Quantitative Research
• Research Ethics
• Scientific Research
• Technologically Savvy

The Anticipated Base Pay Range For This Position Is

€75,500.00 - €117,300.00

Benefits

In addition to base pay, we offer the following benefits* an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees - and in some location’s eligible dependents - can participate in several insurance plans. For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.

• This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.