Research Officer (Junior Postdoctoral)

St Vincent's Institute of Medical Research; Melbourne; On-site; AUD 98,000 - 106,000; Full time

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Job summary

St Vincent's Institute of Medical Research in Fitzroy, VIC, is recruiting a Research Officer (Junior Postdoctoral) to investigate lipid dysregulation in FRDA cardiomyopathy. The role involves lipidomics profiling of iPSC-derived cardiac microtissues and establishing a cardiorenal syndrome model with differentiated kidney organoids.

The successful candidate will join the Cardiometabolic Disease Laboratory on a full-time fixed-term basis (1–2 years), with emphasis on early-career research and

Qualifications

• PhD in a biomedical discipline, recently completed or submitted within ~12 months.
• Data analysis and data management skills are essential.
• Strong laboratory record-keeping and commitment to research integrity.
• Ability to troubleshoot independently while seeking advice when needed.
• Excellent interpersonal and communication skills are required.
• Strong planning and organisational abilities to manage multiple tasks.

Responsibilities

• Investigate lipid dysregulation in FRDA cardiomyopathy using lipidomics profiling of iPSC-derived cardiac microtissues.
• Lead establishment of a cardiorenal syndrome model, differentiating iPSC-derived kidney organoids and studying interactions with cardiac tissues.
• Contribute to collaborative biomedical research environment and document findings meticulously.

Skills

Data analysis

Data management

Lab record-keeping

Troubleshooting

Interpersonal skills

Planning & organisation

Education

PhD in a biomedical discipline

Tools

Fluorescence imaging

iPSC culture

Job description

St Vincent's Institute of Medical Research – Fitzroy VIC

St. Vincent's Institute of Medical Research (SVI)is located on the campus of St Vincent's Hospital Melbourne, is affiliated withThe University of Melbourne, and operates proudly in one of the world's mostdynamic biomedical hubs.

For more than 60 years, scientists at SVI have been inspired by discovery anddriven by purpose. Our team of 250 staff and students work collaboratively totackle some of the most critical health challenges facing society today,including cancer, diabetes, osteoporosis, cardiovascular disease, infectiousdisease and dementia. We celebrate fundamental biological discovery andpractical application alike because both are required to improve the treatment,diagnosis, and prevention of disease. There are no breakthroughs, no new wonderdrugs, no big leaps forward, without new understanding.

The Cardiometabolic Disease Laboratory

The Cardiometabolic Disease Lab uses humaniPSC-derived multicellular cardiac microtissues (combining cardiomyocytes,endothelial cells, smooth muscle cells, and cardiac fibroblasts) and kidneyorganoids to investigate the mechanisms of cardiovascular disease, spanningFriedreich ataxia (FRDA) cardiomyopathy, diabetic cardiomyopathy andcardiorenal syndrome.

The Role

The Cardiometabolic Disease Laboratory arerecruiting a motivated Research Officer (Junior Postdoctoral) to join the teamon a full time, fixed term basis (1-2 years).

This is an exciting opportunity for an early-careerresearcher, ideally someone who has recently completed or submitted their PhD,to develop their postdoctoral research experience within a collaborativebiomedical research environment.

The primary focus of the role will be toinvestigate lipid dysregulation in FRDA cardiomyopathy, using lipidomicsprofiling of iPSC-derived cardiac microtissues to better understand diseasemechanisms and evaluate potential therapeutic strategies. The successfulcandidate will also lead the establishment of a cardiorenal syndrome model,including the differentiation of iPSC-derived kidney organoids andinvestigation of their functional interactions with cardiac microtissues under variousdisease stimuli.

Please refer to the attached PositionDescription for a full description of the key responsibilities.

Who we are seeking

The ideal candidate for the role will have:

• A PhD in a relevant biomedical discipline, either recentlycompleted or submitted within approximately the last 12 months.
• Demonstrateddata analysis and data management skills.
• Stronglaboratory record-keeping skills, with a commitment to research integrity,reproducibility, and accurate documentation.
• Demonstratedability to primarily troubleshoot independently, but also to seek advice whennecessary.
• Exceptional interpersonal and communication skills.
• Strong planning and organisational skills, with the ability to handlemultiple tasks and competing priorities.

Experience in one or more of the following areas will be highlyregarded:

• HumaniPSC culture and directed differentiation would be advantageous, ideallyinvolving cardiac and/or renal lineages.
• Generatingand working with 2D and 3D tissue models.
• Live-cellassays and fluorescence imaging.
• Lipidomicsample preparation and/or data interpretation.

To be considered for the role, you must have appropriate rights inAustralia to work full-time for the duration of the appointment. The successfulcandidate will also be required to undergo a Nationally Coordinated CriminalHistory Check prior to commencement.

Salary:

$98,381-$105,506 per annum (full-time) plus 12% superannuation. Salaryapplied will be dependent upon successful candidates' current level, experienceand qualifications). In addition to your base salary, we offer up to $15,900FBT exempt salary packaging and up to $2,650 FBT exempt meals andentertainment packaging.