Lead Scientist - Functional Immunology*

Bio-LogX FlexCo; Wien; Vor Ort; EUR 50.000 - 61.000; Vollzeit

Benefits dieser Stelle

Competitive compensation

Team leadership

Professional growth

Vienna location

Zusammenfassung

Bio-LogX FlexCo in Vienna is seeking a Lead Scientist – Functional Immunology to design and execute in vitro immune assays and translate findings into clinical concepts. You will oversee data interpretation, contribute to strategy, and collaborate with CRO partners in translational studies.

The role requires a PhD in immunology or related field, 3+ years’ post-PhD experience, and strong communication skills in English.

Qualifikationen

• PhD in Immunology, Oncology, Cell Biology, or related field.
• At least 3 years of relevant work experience after PhD.
• Hands-on expertise in immune-cell biology and assays.
• Experience with CROs and external collaborators.

Aufgaben

• In-house assay development and optimization of functional assays.
• Evaluate cytokine biology and co-culture systems for functional studies.
• Characterize mechanism-of-action and target engagement in vitro.
• Coordinate studies with CRO partners including in vivo and ex vivo models.
• Analyze data, present to team, and contribute to study design.
• Supervise and mentor lab technicians.

Kenntnisse

immune-cell biology

cellular assay development

data interpretation

team mentoring

CRO coordination

Ausbildung

PhD in Immunology or related field

Tools

Flow cytometry

Jobbeschreibung

As Lead Scientist – Functional Immunology you will join our research team in Vienna and help us bring next generation drugs from the bench into the clinic. In this position you will design, establish and execute functional assays, analyze and interpret data, and contribute to the translational evidence package supporting clinical proof-of-concept studies.

Your main responsibilities will be:

• In-house assay development.Design, optimize, and execute in vitro functional assays to evaluate the activity of lead molecules and generate data to support mode of action studies and drug candidate selection, including immune and tumor cell co-culture systems for functional studies, T-cell activation assays and cytokine release assays
• Cytokine biology. Evaluate cytokine-mediated biological activity and support head‑to‑head selection of engineered cytokine variants, including JAK/STAT activation assays and receptor‑bias characterization as well as T-cell activation assays
• Mechanism‑of‑action and target‑engagement studies. Develop and execute in vitro studies to characterize target engagement, pharmacological profiling, and downstream biological responses of lead molecules.
• CRO coordination.Coordinate and oversee studies conducted with CRO partners, including in vivo efficacy models (e.g. humanized and knock‑in mouse models) and ex vivo translational models (patient tumor fragments / organoids).
• Data interpretation and communication. Analyze and interpret the data, present it to the project team and management, and contribute to study design and program strategy.
• Supervision and mentoring of lab technicians

Your profile

What you have to offer:

• PhD in Immunology, Oncology, Cell Biology, or a related field.
• At least 3 years of relevant work experience following your PhD (preferably in a biotech or pharma setting).
• Hands‑on expertise in immune‑cell biology and cellular assay development.
• Practical experience with primary human immune cells, dendritic cells and T cells, multicolor flow cytometry, cytokine analysis, and functional immunology assays.
• Experience working with CROs and external collaborators.
• Good organizational, communication, and data‑interpretation skills, and the ability to work well within a small team.
• Track record of scientific excellence, including publications and patent applications.
• Proficiency in English (written and spoken).
• Strong candidates will also offer one or more of the following:
  • Experience with co‑culture/tri‑culture systems (e.g. dendritic cell–T cell–tumor).
  • Experience in early‑stage drug discovery and preclinical development.
  • Familiarity with cytokine/cytokine‑mutein biology, JAK/STAT signaling, and Treg vs. effector readouts.
  • Experience with ex vivo patient‑tissue or organoid models.

Why us?

Benefits for you.

• Take responsibility for a key research field within Bio-LogX and bring new immunology based treatments to patients
• Lead and develop a team of highly skilled researchers and work closely with our bio‑informatics, generative protein design and disease modeling teams.
• Pioneer new methods and processes to industrialize key research techniques.
• Be part of a highly motivated, multinational and fun team that believes protein based modalities can become next‑generation medicines for patients.
• competitive compensation package that reflects the qualifications and seniority of the candidate and may include further, e.g. performance‑based, incentives. Due to legal requirements, we are required to state that minimum salary for this job is a monthly salary of EUR 4.500,-- gross, where candidates with extensive experience can expect to earn EUR 5.500,-- and more.

About us

Bio-LogX FlexCo (currently being renamed to Sameric Bio), based at the Vienna Biocenter, is a VC‑backed therapeutic engine. We develop drug candidates from animal to clinical proof of concept – always with the ambition to transform the standard of care. We are agnostic about therapeutic area but focus on protein modalities: antibodies, enzymes, fusions, engagers, degraders, agonists, antagonists.